New Scientist, January 29, 2009
By Sharon Oosthoek
One hundred years ago in a lab at Harvard University, a young zoology student was busily overseeing the breeding of pair after pair of brother and sister mice. The “Mouse Man”, as he was known on campus, was trying to create the first inbred lab animal – a strain of mouse whose genes would be stable and identical. Such a mouse would allow biologists to reliably replicate their experiments for the first time. His professor said it couldn’t be done, but the Mouse Man proved him wrong. We are all indebted to those inbred mice and their descendants, which have helped researchers develop treatments for a wide range of human diseases.