Sharon Writes

August 22, 2009

CONSERVATION: Human intervention gone awry

Filed under: Globe and Mail, Magazines and newspapers — Sharon @ 11:31 am

The Globe and Mail, Saturday, August 22, 2009

Condemned to death: What happens when a rescue plan works too well

By Sharon Oosthoek

Thirty years ago, the cormorant was a poster bird for the campaign to clean up DDT, the pesticide killing creatures here and abroad. The Great Lakes, home to 900 nesting pairs in the early 1950s, had a mere 125 by 1973, with scientists unable to find even a single pair on Lake Michigan or Lake Superior.

Photos showing chicks born with crossed beaks and unable to feed led to public outrage and a reduction in use of the chemical, giving the bird a chance to bounce back.

Double-crested cormorant. (Courtesy Parks Canada)

Double-crested cormorant. (Courtesy Parks Canada)

And bounce back it has. Today, the cormorant is more numerous on the Great Lakes than at any time in recorded history. Now the “crow ducks” are so common that some of them have been condemned to death – a bizarre state of affairs for a species so recently in peril.

In fact, says Mark Ridgway, a biologist with the Ontario Ministry of Natural Resources, it’s the first time in Canada “we’ve gone from having an organism that’s a rarity to having a management issue. No one’s confronted this before.”

The cormorant has become one of the growing number of cases in which human intervention, however well-meaning, has had unintended consequences.

From elephants in South Africa to alligators in Florida and even the newly reintroduced plains bison in Saskatchewan, wildlife managers accustomed to dealing with endangered species are starting to confront some that have become “hyper-abundant.” Animals once in grave danger have become a threat to others.

So what is a responsible conservationist to do – let nature run its course and hope for the best or, to paraphrase George Orwell, kill the cormorants because some lives are more sacred than others?

(more…)

August 6, 2009

Alzheimer Society of Ontario – Meet our researchers: Adam Proctor

Alzheimer Society of Ontario website

August 2009

Meet our researchers:  Adam Proctor

If Alzheimer’s drug development were a military campaign, Adam Proctor would be on the reconnaissance team gathering intelligence on the enemy before battle.

As a lab technician at the University of Toronto’s Centre for Research in Neurodegenerative Diseases, Proctor helps piece together the enemy’s strategy. Specifically, he helps figure out how a group of four proteins called gamma-secretase is able to snip a long protein into fragments called beta-amyloid.

"Alzheimer's is a really difficult disease to figure out. It sounds silly to say, but if it were easy, it would be cured by now," says Adam Proctor. (Photo by John Rennison)

"Alzheimer's is a really difficult disease to figure out. It sounds silly to say, but if it were easy, it would be cured by now," says Adam Proctor. (Photo by John Rennison)

Why is that important? Because beta-amyloid accumulates in the brain to form the plaques thought to be responsible for the disease.

“If you get a result from an experiment that’s really good, you wonder if this is the next step that will lead us down a path to cure the disease,” says Proctor, 26.

Proctor, who has a Masters degree in molecular biotechnology, has been fascinated by proteins and human disease since taking an advanced biology class in high school.

That’s where he first learned the secret to understanding how proteins work: their shape. Proteins, like gamma-secretase, can only interact with other proteins if they have the right shape — sort of like a key fitting into a lock.

“Everything in molecular biology is determined by shape,” says Proctor. “Molecular biology is about stuff bumping into other stuff. If it fits together, something happens. If it doesn’t, nothing happens.”

Proctor’s job at the Centre is to grow cells that have been genetically altered to produce large quantities of gamma-secretase proteins. He then hands over those proteins to researchers at the Centre who try to determine their shape.

Once they figure that out, it may one day be possible to develop drugs to alter those shapes so that the gamma-secretase proteins can no longer do their destructive work.

It is, Proctor says, basic research that is still years away from yielding effective treatment for Alzheimer’s disease. But understanding the enemy is half the battle.

“Alzheimer’s is a really difficult disease to figure out. It sounds silly to say, but if it were easy, it would be cured by now,” he says. “But we are making progress. There is definitely hope out there.”

The Centre for Research in Neurodegenerative Diseases provides international leadership in research, education and discovery related to neurodegenerative diseases. The Alzheimer Society of Ontario is a co-founder and lead funder of the Centre.

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